Thursday, 2 February 2017

Corruption and the Looming Health Crisis in Malawi—Are we fiddling while Rome burns?



When people talk of corruption as an incubus in the health sector, their eyes are often set on the consequences of that large scale corruption at Capitol Hill, Malawi’s seat of Government, the scandal that forced the donor community to withdraw budgetary support to the country, leaving the poor to pay for the sins of their masters—a select elite entrusted with the duty to defend and protect the public purse. It is true that following revelations of corruption of obscene nature in the civil service, the Western world had reacted by quickly withdrawing budgetary support, and this has dealt the health sector a telling blow. Most hospitals and health clinics now run on inadequate supplies. This is just one of those burdens corruption has brought on the Malawi race. But to measure the true breadth and length of corruption in the public health sector, we need to go deeper than this. This is what I will do in this discussion, digging deeper in order to demonstrate that corruption, apart from depriving the poor of the much-needed drugs and other equipment useful in any hospital setting, also triggers a devastating undercurrent whose consequences are dire and can harm alike both the culprit rich and the victim poor. I will thus demonstrate that we are standing on the edge of a chasm, and that if corruption in the health sector is not checked once and for all, the evil threatens to bring upon us all a catastrophe nothing human can cope with.

Corruption, hospital supplies and deaths
Corruption affects hospital supplies in a number of ways, directly and indirectly. First, grand corruption in the public sector gives the fatigued donor community a reason to flee the scene, often abandoning projects mid-way, some of which were directly involved in procurement and purchase of drugs and equipment for our hospitals and clinics. That way, the health sector simply collapses, forcing hospitals and clinics to live in names only. The unavailability of essential drugs and equipment in hospitals means absence of treatment, and the result is that simple ailments end up getting complicated, eventually leading to more complications and deaths. In this way, corruption by a few greedy fools ends up punishing the poor masses, people with nothing to hold on to. Eventually, through corruption by a few greedy foes, the cycle of poverty continues, taking a more virulent strain at every turn.

Corruption also leads to further spread of diseases which, otherwise would have been contained in the early stages. This is exactly what happened in Sierra Leone some three years ago. Sierra Leone is among the West African countries that were hard hit by Ebola then. In that country alone, the disease killed nearly 4,000 people. Among this number were 200 health workers in that country.

Latest audit revelations in that country show that some of those deaths could not have occurred if the funds from both national coffers and private donations released towards fighting the deadly virus there had been used for the intended purpose. But as it was, some people had diverted a large chunk of that money for their own private end, accepting to see their country go down because they wanted to earn where they did not sow. One can just imagine what they say now after the level of devastation they had caused upon their own people! So many thousands of people who should have contributed in some significant way to the growth and development of Sierra Leone were sent to an untimely grave, thanks to corruption in the high places.

In one article by Umaru Fofana of the BBC entitled “Where are Sierra Leone’s missing Ebola millions” dated 23 January 2017 and available at www.bbc.com, Alhassan Kemokai, a survivor from the disease wishes all the essential supplies had reached the hospitals, for then many lives would have been saved. The article says this gentleman had contracted the disease from his mother who was a hospital worker and that she had contracted it while helping an unsuspecting Ebola patient. Sadly, she mother succumbed to the illness, and article quotes Mr Kemokai as saying his mother would not have contracted the disease if the hospital where she was working had basic things such as gloves. In other words, if those entrusted with disbursing money meant to contain Ebola in Sierra Leone had exercised that high level of honesty expected of people in that position, Sierra Leone would not have lost up to 4,000 people to Ebola.

According to Jamie Hitchen in “Sierra Leone: Mismanagement of Sierra Leone’s Ebola Spending”, available at www.allafrica.com, a report by the country’s Internal Auditor had found that as much as 30% of the approximately US$19 million meant for the fight against Ebola in May-October 2014 alone, had been disbursed without proper supporting documents. According to the article, in some cases, hospital ghost workers were created and paid for using money meant to fight the disease.

In short, where people indulge in corruption especially in a context of some health crisis, the result is devastating especially among those front-line hospital workers as well as the people coming to access the services. Because they are not being given essential hospital supplies, these workers end up contracting the disease, in some cases leading to deaths, all this in a context where it is a toll order to train medical personnel. On the other hand, the people seeking medical help end up losing their lives after receiving no proper treatment owing to lack of resources following diversion of funds meant for the purchase of hospital supplies and drugs.

Another devastating consequence of corruption to the health sector is something most of us do not take time to think on—the issue of antimicrobial resistance or simply drug resistance.

Corruption and drug resistance
According to the World Health Organization “antimicrobial resistance happens when microorganisms (such as bacteria, fungi, viruses, and parasites) change when they are exposed to antimicrobial drugs (such as antibiotics, antifungals, antivirals, antimalarials, and anthelmintics). Microorganisms that develop antimicrobial resistance are sometimes referred to as ‘superbags’” (“Antimicrobial Resistance” Fact sheet, available at www.who.int, updated September, 2016, accessed 2 February 2017).

The term antimicrobial resistance is thus an umbrella term for all drug resistance posed by bacteria, viruses, fungi and parasites. If the resistance is caused by bacteria it is referred to an antibiotic resistance.

Antimicrobial resistance is becoming serious by the day and “medical pundits are now warning of a return to the pre-antibiotic era; a recent database lists the existence of more than 20,000 potential resistance genes (r genes) of nearly 400 different types, predicted in the main from available bacterial genome sequences” (Julian Davies and Dorothy Davies, 2010: 147). In other words, what is happening as far as drug resistance is concerned is as if we are going back to the era before various antibiotics were discovered, the era when a slight bacterial or viral attack would end up in deaths of many.

But what are the dangers of drug resistance?

According to Dr Tom Frieden in Antibiotics Resistance Threats in the United States, 2013, p 5: “When first-line (those standard drugs or therapy ordinarily used for a particular pathogen or parasite) and then second-line (those used after those we normally rely on have failed) antibiotic treatment options are limited by resistance or are unavailable, healthcare providers are forced to use antibiotics that may be more toxic to the patient and frequently more expensive and less effective. Even when alternative treatments exist, research has shown that patients with resistant infections are often much more likely to die, and survivors have significantly longer hospital stays, delayed recuperation, and long-term disability.”

The threat of drug resistance is real. According to the World Health Organization Antimicrobial Resistance: Global Report on Surveillance 2014, “Globally, 3.6% of new TB cases and 20.2% of previously treated cases are estimated to have multidrugresistant TB (MDR-TB” p xii.

The same report says that “the yearly cost to the US health system alone has been estimated at US $21 to $34 billion dollars, accompanied by more than 8 million additional days in hospital” p xix. I am sure that estimates for an African country of the stature of Malawi would be mind-boggling.

Today I read an article by James Gallagher on the problem of resistance on malaria. The article entitled “Malaria drugs fail for first time on patients in UK” says doctors in the UK have said that “a key malaria treatment has failed for the first time in patients being treated in the UK.” The article says between October 2015 and February 2016, four people there were treated with artemether-lumefantrine (also known as Coartem) which is a combination drug, and they responded to it only to be readmitted when the infection reappeared. All the four had contracted the parasite when two visited Uganda, one Liberia, and the other one, Angola. This suggests that there could be a type of parasite spreading in Africa resistant to malaria drugs. However, the article quotes a team at the London School of Hygiene and Tropical Medicine that it was too early to panic.

On the cause of resistance, Davies and Davies, say, “The development of generations of antibiotic-resistant microbes and their distribution in microbial populations throughout the biosphere are the results of many years of unremitting selection pressure from human applications of antibiotics, via underuse, overuse, and misuse” p 419.

The World Health Organization 2001, also speaks of underuse, overuse and misuse when it says, “The emergence of antimicrobial resistance is a complex problem driven by many interconnected factors, in particular the use and misuse of antimicrobials” WHO Global Strategy for Containment of Antimicrobial Resistance, p 3. It is therefore important that “antimicrobial drugs (i.e. the drugs we use against bacteria, viruses, fungi and parasites) be used exactly as they are prescribed, or else they can contribute towards antimicrobial resistance” (“What is Antibiotic Resistance? What is Drug Resistance?” by James McIntosh, available at www.medicalnewstoday.com, updated January 22, 2016).

Corruption can force the people to practise underuse and misuse of antibiotics or indeed any drug.

The other day a friend of mine working in the health sector told me a story of how one security guard went to a hospital where he was given some antibiotics after diagnosis. The security guard who was able to read noticed a discrepancy between the prescription on the cover of the medicine bag and the number of capsules inside it. He went to his boss and asked whether this was normal. It was not normal, he was told, and the boss took up the matter where it was found there was a kind of syndicate whereby a few pills were being removed into a separate collection, for money.

The guard in question was able to read and detect the discrepancy, but the majority of Malawians are illiterate. In other words, they can take in whatever can be given them, taking for gospel truth everything the nurse or medical assistance or clinical officer can give them. Indirectly, such people can be forced to ‘abuse’ or ‘misuse’ the drug, a situation that can lead to drug resistance. This is the reason my brother or sister on antiretroviral therapy is entreated to always take the medication as prescribed in order to keep the infection to a mere chronic, manageable condition, thus enabling one to live as normal as everybody else. Unfortunately, the moment one stops taking their medication, the virus which is never eliminated but remains dormant or inactive in some immune cells starts replicating or multiplying again, and the consequences can be dire. This is why antiretrovirals have to be taken for life, the very point stressed by the World Health Organization when it observes: “To limit the impact of HIV drug resistance on the effectiveness of ART, it is essential to ensure high quality treatment and care services” p 53. But how can we ensure high quality treatment and care services when the resources meant to meet these services are diverted through corruption? Indirectly thus, corruption can lead to drug resistance through provision of low quality treatment and care services.

But how can the situation affect those practising corruption eventually?

Misuse of drug prescription can force the virus or bacterium to acquire a more formidable appearance, forcing the body to fail to respond to that new threat regardless of the nature of medicine administered. The danger with this is that drug resistance spreads beyond the one in whom the virus or bacterium has strained. Put simply, if a bacterium turns into a strain or form that will not die after administration of a drug that normally kills it, bacteria born from that bacterium will equally or even more refuse to respond to that drug. If bacteria of that strain spread into other people, their bodies too will fail to respond to a drug that would normally kill or eliminate those bacteria. If this can spread in the environment in which we live, the situation eventually becomes a danger to us all, those practising corruption inclusive.

One way to prevent drug resistance is to make a “commitment to always use antibiotics appropriately and safely—only when they are needed to treat disease, and to choose the right antibiotics and to administer them in the right way in every case—(and this) is known as antibiotic stewardship” Antibiotic Resistance Threats in the United States, 2013, p 30. But this is never easy where corrupt officials use people’s ignorance by giving them low quality treatment and services, having diverted a large chuck of the same to sell for their personal end.

Corruption has also forces people to lose faith in public hospitals. As a result some people just resort to finding their own means of getting the drugs through buying from unauthorized dealers who can give them wrong prescription. This may end up creating an environment in their bodies for microbes to develop resistance.

A person who buys drugs from some unqualified person by the roadside, the drugs themselves stolen from some public health warehouse, pharmacy or dispensary, such a person may end up overusing or underutilising the drugs. It is common to find people buying only a few pills because they do not have enough money, and stop taking the drug once the pills they bought have been consumed.

It is important to note that “(such) societal factors accelerate the spread of resistance. Undertreatment through suboptimal doses or inadequate treatment durations—for example, when a patient does not complete a prescribed course of antibiotics—leads to resistant strains of disease-causing microorganisms. Resistance is also encouraged by unnecessary treatment of viral or noninfectious diseases with antibiotics and the use of broad-spectrum drugs in patients whose infections could be treated with more-targeted drugs” Health Affairs, September 2010, Aaron S Kesselheim and Kevin Outterson, p 1690.

Although WHO and other organisations rarely talk of corruption as a possible contributor to drug resistance through forcing the people to abuse or misuse drugs, a deep tracking of the link shows a strong connection between corruption and development of drug resistance in viruses, bacteria, parasites, and fungi.

Conclusion
The fight against corruption though crucial elsewhere, has a more telling implication in the health sector because one can be forced into drug abuse and misuse out of poverty and ignorance. Those indulging in the evil must realize that they are creating for this population a dirty bomb of sorts in antimicrobial resistance, and GOD forbid, if such can strike, we cannot escape each other, for nature always finds a way for us all to interact in some form. I am talking about those forms.

References
Aaron S Kesselheim and Kevin Outterson (September, 2010) “Fighting Antibiotic Resistance: Marrying New Financial Incentives to Meeting Public Health Goals” Health Affairs

Fergus Walsh, “Why talk of a cure for HIV is premature” dated 3 October, 2016 available at www.bbc.com accessed 1 February, 2017

James Gallagher, “Malaria drugs fail for first time on patients in UK” dated 31 January 2017, avaible at www.bbc.com accessed 1 February 2017

James McIntosh, “What is Antibiotic Resistance? What is Drug Resistance?” available at www.medicalnewstoday.com, updated January 22, 2016, accessed 2 February 2017

Jamie Hitchen, “Sierra Leone: Mismanagement of Sierra Leone’s Ebola Spending”, available at www.allafrica.com, accessed 1 February 2017

Julian Davies and Dorothy Davies, 2010, “Origins and Evolution of Antibiotic Resistance” Microbiology and Molecular Biology Reviews,74(3). American Society for Microbiology

Umaru Fofana, “Where are Sierra Leone’s missing Ebola millions” dated 23 January 2017, available at www.bbc.com, accessed 1 February 2017

World Health Organization, World Health Organization Antimicrobial Resistance: Global Report on Surveillance 2014

World Health Organization 2016 “Antimicrobial Resistance” Fact sheet, available at www.who.int, updated September, 2016, accessed 2 February 2017)

WHO 2001, WHO Global Strategy for Containment of Antimicrobial Resistance

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